• In the mid-1990s, Alzheimer’s disease began eroding my father’s brain, and medicine had nothing to offer him or millions of other Americans.
• Recently, a drug called lecanemab has been heralded as a breakthrough, but it only slightly slows a patient’s inevitable decline for a few months.
• The amyloid hypothesis has held a vise-like grip on Alzheimer’s research for decades, despite the fact that drugs designed to address amyloid have shown virtually no beneficial effects on patients.
• The incentives of big academic medicine, big governmental medicine, and big pharma have contributed to the persistence of the amyloid theory, despite the lack of evidence.
• Scientists whose ideas fell outside the dogma have recounted how, for decades, believers in the dominant hypothesis suppressed research on alternative ideas.
• Journals have turned down research papers and grants have been rejected, leading some talented researchers to other fields.
• The FDA recently approved the drug aducanumab, which has been met with criticism due to its ineffectiveness and high cost.
• Biogen and Eisai are now pushing for the approval of lecanemab, which has been touted as a “gamechanger” for Alzheimer’s treatment.
• Clinical trials of lecanemab showed a 0.45 point improvement on an 18-point scale, and three patients died from brain swelling and bleeding as a result of the treatment.
• There is concern that the focus on amyloid-targeting drugs will divert resources away from other possible treatments, such as anti-herpes drugs, antibacterials, and “cocktails” of drugs.
Published January 4, 2023. Visit The Free Press to read the original post.