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Will CRISPR Cure Cancer? [Brian Gallagher, Nautilus]

W

• Brad Ringeisen, chemist and executive director of the Innovative Genomics Institute, is working on two approaches to deliver CRISPR-Cas9 treatment to target cancer cells.
• The first approach is to use antibodies to bind to something that’s only found on a specific cell type.
• The second approach is to use envelope delivery vehicles, which take certain parts of a virus’ targeting system to help specifically target a certain cell type or tissue type.
• Intellia Therapeutics has already shown that CRISPR-Cas9 treatment can be applied intravenously to treat a liver disease.
• The dream is to do an infusion and then monitor the patient for a day or two, as this would be the most efficient and successful way to treat cancer with CRISPR-Cas9.

Published February 14, 2023
Visit Nautilus to read Brian Gallagher’s original post Will CRISPR Cure Cancer?

Contra Kavanagh On Fideism [Scott Alexander, Astral Codex Ten]

C

• Chris Kavanagh recently tweeted about Scott Alexander’s article on Ivermectin, criticizing the rationalist community for ignoring conspiracy ecosystems and how they distort things.
• Rachel responded to Chris’ tweet, suggesting that the article may have persuaded some people to get vaccinated instead of taking Ivermectin.
• Chris responded to Rachel, saying that his critique was orientated towards the rationalist community and what it says it does vs. what he sees.
• The author shares a personal story of how he was once a believer in a conspiracy theory, and how anti-conspiracy bloggers and podcasters could have saved him from a five year wild-goose-chase, but chose not to.
• Kavanagh’s criticism of the author’s 25,000 word essay on ivermectin is accepted, but not from him, as he has devoted his career to the subject.
• The author interprets Kavanagh’s comment as suggesting that it is a mistake to even try to evaluate the evidence, as it suggests there might be evidence on both sides.
• The author points out that there were actually thirty different studies that supported ivermectin, and it was adopted in several countries.
• The author compares Kavanagh’s comment to fideism, the belief that someone who reasons their way to belief in God is a sinner.
• The author argues that the PR argument of Kavanagh’s comment looks bad, as it suggests that doing good science is a near occasion of sin for doing bad science.
• The author argues that conspiracy theorists have the same biases as everyone else, but are slightly worse at applying CONSTANT VIGILANCE.
• The author uses the example of premenstrual dysphoric disorder to illustrate how it is not obvious how to apply the heuristic “trust experts”, and how both sides were trying to make the reader short-circuit their thought process.
• The author argues that it is important to have tolerance for others forming their own opinions, and for science communicators to help guide people through this process.

Published February 15, 2023
Visit Astral Codex Ten to read Scott Alexander’s original post Contra Kavanagh On Fideism

If Technology Only Had a Heart [Sian E. Harding, Nautilus]

I

• The history of the total artificial heart is punctuated with both brilliant innovation and continual clinical failure.
• In 1964, President Lyndon B. Johnson funded a program to develop the first functional self-contained artificial heart.
• The first total artificial heart was implanted in 1969, but a reliable off-the-shelf version is still out of reach.
• The original goal was to replace the failing heart completely, but the goal changed to keeping the patient alive until a transplant donor could be found.
• The development of ciclosporin in the early 1980s dramatically improved the success of heart transplantation.
• Ventricular assist devices (VADs) take blood out of the ventricle of the heart and push it into the aorta at high pressure.
• Left ventricular assist devices (LVADs) have become a therapy in themselves, with survival rates of over 50 percent seen at seven years.
• Solutions for a completely implantable total artificial heart seem tantalizingly close, but no one is anticipating an easy ride.

Published February 14, 2023
Visit Nautilus to read Sian E. Harding’s original post If Technology Only Had a Heart

Review: Patrick Bringley’s “All the Beauty in the World” [Freddie deBoer, Freddie deBoer’s Substack]

R

• Patrick Bringley’s book, *All the Beauty in the World: The Metropolitan Museum of Art and Me*, tells the story of his ten years as a guard at the museum and what he learned about the institution and its collection.
• The book provides an intimate look at the operations of the Met and its art, as well as anecdotes about the many colorful characters Bringley met among the museum’s visitors.
• Bringley handles the connection with his brother’s death deftly, creating new insight and inspiring the intended emotions.
• The book has a bit of an overwriting problem, with Bringley stretching for images and metaphors that don’t quite work.
• The book ultimately serves as a book-length advertisement for reconnecting with the visual arts, encouraging readers to visit the museum and experience something uncommon or unexpected.

 

Math Is Magic [Camonghne Felix, The Atlantic]

M

• In second grade, the author suddenly stopped being able to do math, and her mother connected the dots between her sudden inability and the violent trauma she was experiencing.
• She was labeled an underperformer and troublemaker, and eventually transferred to an alternative high school, where a teacher saw something in her and tutored her during lunch.
• After graduating, she was diagnosed with severe ADHD and bipolar 2 disorder, which can affect cognitive skills and executive function.
• After months of treatment, her ability to compute improved, and she now approaches mathematics from a place of wonder and admiration.
• She now enjoys splitting the bill with her friends, as it gives her the chance to correct the narrative of the past.

Published February 14, 2023
Visit The Atlantic to read Camonghne Felix’s original post Math Is Magic

New Bing Errors, User Preferences and Company Reputations, Section 230 and LLMs [Ben Thompson, Stratechery]

N

• Microsoft’s Bing AI demo contained multiple errors, which went unnoticed until Dmitri Brereton pointed them out.
• Brereton’s diligence highlighted the importance of verifying AI-generated data.
• Microsoft’s enthusiasm for the technology and eagerness to take on Google may have led to the errors.
• Google’s reputation and user base make it difficult to balance accuracy and user demand.
• Section 230 may not apply to large language models, raising questions of liability for libel.
• Humans may not care about accuracy, as the humanization of computers may be alluring enough to gain traction.

Published February 14, 2023
Visit Stratechery to read Ben Thompson’s original post New Bing Errors, User Preferences and Company Reputations, Section 230 and LLMs

The truth about Biden, the GOP, Social Security, and Medicare [Judd Legum, Popular Information]

T

• President Joe Biden has been criticized by major media outlets and Republican officials for his claims that Republicans are proposing cuts to Social Security and Medicare.
• The Republican Study Committee (RSC) proposed a 2023 budget that would cut Social Security and Medicare benefits by increasing the retirement age and changing the benefit formula.
• Congressman Buddy Carter (R-GA) and Senator John Thune (R-ND) have both called for cuts to Social Security and Medicare.
• Senator Rick Scott (R-FL) proposed a plan to “sunset” all programs after five years, including Social Security and Medicare.
• Biden’s real vulnerability on the issue stems from his own efforts to cut Social Security and Medicare years ago.
• However, Biden has since changed his position and proposed to increase Social Security benefits, not freeze them.

Published February 14, 2023
Visit Popular Information to read Judd Legum’s original post The truth about Biden, the GOP, Social Security, and Medicare

The Witch Trials of J.K. Rowling [Megan Phelps-Roper, The Free Press]

T

• J.K. Rowling is one of the most successful authors in history, and her “Harry Potter” series has taught millions of children about virtues like loyalty, courage, and love.
• In 2020, Rowling sparked a global controversy when she tweeted her views on sex and gender issues.
• This led to a “revolt” among her publishers, an outcry from fans, and a torrent of negative headlines.
• In response, Rowling published an essay on sex and gender issues, including an account of her abusive ex-husband.
• In the late 1990s and early 2000s, many Christians saw her stories of witchcraft as dangerous and campaigned to have her work removed from schools and libraries.
• The author Elyanna Blaser-Gould wrote Rowling a letter, asking to interview her about her views and experiences.
• Rowling agreed, and Blaser-Gould spent time with her in Scotland, speaking with her and other people on all sides of the conflict.
• The Witch Trials of J.K. Rowling podcast will begin on February 21, 2021.

Published February 14, 2023
Visit The Free Press to read Megan Phelps-Roper’s original post The Witch Trials of J.K. Rowling

Don’t give up on police reform [Matthew Yglesias, Slow Boring]

D

• Reactions to the video of Tyre Nichols’ apparent murder at the hands of Memphis Police Department officers were understandably strong.
• D’Zhane Parker from the Black Lives Matter Global Network Foundation put out a statement bluntly saying Nichols’ death “affirms what we’ve known all along: Reform doesn’t work.”
• Major changes for the better have occurred in the history of American policing, including anti-corruption measures and a shift in understanding of what police officers should be doing.
• Rep. Summer Lee appeared on Face The Nation and said “less than 2% of police officers who are engaged in misconduct are ever indicted at all.”
• Body cams generate evidence that can inform investigations after police shoot someone, and can bolster police legitimacy by demonstrating that they’re not just making stuff up.
• Alex Vitale’s book “The End of Policing” notes that successful reform is good, and that reformers need to identify and publicize good ideas and remind people that change is possible.
• Rachel Cohen’s article on body cams suggests they lead to an approximate 10% reduction in police use of force.
• Evidence suggests that a sustained allegation against a police officer reduces their future misconduct, and that routine increases in oversight lead to less misconduct and no change in crime.
• Reform of police misconduct is hard, not because of technical aspects, but because it requires time and effort to convince people to change the standards.
• Diversifying police forces can help ameliorate racial bias, but it requires money and social capital to encourage people to want the job.
• Holding officers to a higher standard of conduct will cost more money, not less.
• Taking the need for quality policing seriously and investing the time and money to do it is the best approach, rather than throwing one’s hands up and declaring the whole thing hopeless.

Published February 14, 2023
Visit Slow Boring to read Matthew Yglesias’s original post Don’t give up on police reform

Band Breakups Are No Simple Thing [Caroline Mimbs Nyce, The Atlantic]

B

• Panic! at the Disco announced their separation after 19 years, with lead singer Brendon Urie citing his focus on family as the reason.
• Nabil Ayers, a drummer turned record-label executive, explains that a band is like a company, and often is a company, with different agreements between members.
• Ayers discusses the difference between a band breakup and a reunion, and the role of fans in the internet age.
• He also explains that breakups can be seen as a marketing tool, but that they can also be a way for members to gain freedom and pursue other interests.

Published February 14, 2023
Visit The Atlantic to read Caroline Mimbs Nyce’s original post Band Breakups Are No Simple Thing

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